Indian scientists reveal how SPIN90 turns on a key cell “builder”
A team of scientists based at CSIR-Centre for Cellular and Molecular Biology (CCMB) in Hyderabad, India has solved an important piece of how cells build their internal skeleton. Using cryo-electron microscopy, the researchers showed how a protein called SPIN90 forms a pair and activates the Arp2/3 complex to start new actin filaments. This work explains a long-standing mystery about how straight actin filaments can be made inside cells and helps us understand cell movement, shape and some disease processes.
